Description
Product Characteristics:
Calcyclin, also known as Protein S100-A6, growth factor-inducible protein 2A9, S-100 calcium-binding protein A6 (S-100A6) or MLN 4, is a homodimeric member of the S-100 calcium-binding protein family whose expression is upregulated in proliferating and differentiating cells. Calcyclin is inducible by growth factors and overexpressed in acute myeloid leukemias. It is expressed in a cell-specific manner in subpopulations of neurons and astrocytes and in epithelial cells and fibroblasts. Calcyclin is a specific target of S-100B protein in vivo. The binding of Calcyclin to S-100B is stabilized by S-100B-bound calcium and zinc. Calcyclin associates with both Annexin XI and CacyBP (calcyclin-binding protein). It functions to activate several processes along the calcium signal transduction pathway including the regulation of cell growth, proliferation, secretion and exocytosis.
Subcellular location: Cytoplasm, Nucleus, Cell membrane
Synonyms: S100 alpha 6 PRA, Calcyclin, PRAGrowth factor inducible protein 2A9, Prolactin receptor associated protein, Prolactin receptor-associated protein, Protein S100 A6, Protein S100-A6, S100 A6, S100 calcium binding protein A6 calcyclin, S100 calcium binding protein A6, S100 calcium-binding protein A6, S100A6, S100A6_HUMAN, S100-A6, 2A9, 5B10, CABP, CACY, Calcyclin, Growth factor inducible protein 2A9, Growth factor-inducible protein 2A9, MLN 4, MLN4.
Target Information: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008]